Studies have shown that the abnormality of the PI3K-AKT cell signaling pathway is believed to be related to the pathogenesis of AKI and has a great impact on apoptosis and inflammation induced by AKI, as well as chronic renal insufficiency induced by long-term AKI.[21,22] The GO and KEGG enrichment pathway analysis results indicate that the key genes detected in this study may take place in the occurrence of AKI via the above pathways. The gene discussed is AKT1; the disease is acute kidney injury.