AKT1 and chronic kidney disease: Studies have shown that the abnormality of the PI3K-AKT cell signaling pathway is believed to be related to the pathogenesis of AKI and has a great impact on apoptosis and inflammation induced by AKI, as well as chronic renal insufficiency induced by long-term AKI.[21,22] The GO and KEGG enrichment pathway analysis results indicate that the key genes detected in this study may take place in the occurrence of AKI via the above pathways.