Compounds 7, 8, and 9 (Figure 2) were previouslyidentified utilizing an in silico chemical databasefingerprint search of the Enamine REAL collection.46 Evaluation of [3H]7 and [3H]8 in post-mortem human AD, PSP, CBD, and PiD braintissue homogenates demonstrated that these compounds bind with highaffinity to aggregated tau, yet 7 and 8 didnot compete effectively against [3H]2 or thestructurally similar aryl-indole [3H]5 inAD, PSP, and CBD brain tissue homogenate assays. This evidence concerns the gene MAPT and Alzheimer disease.