In addition, circASCC3 was more stable than the linear transcripts of ASCC3 and CDKN1A (usually known as p21), as it exhibited prolonged half-life in cancer cells when transcription was blocked by Actinomycin D (Fig. 1F) and was resistant to RNase R digestion (Fig. 1G). The gene discussed is CDKN1A; the disease is cancer.