The pattern of DLK-induced neuronal death shares similarity to the differential vulnerability of CA1 and CA3 neurons reported in patients with Alzheimer’s disease (West et al., 1994), and animal models of oxidative stress (Wilde et al., 1997), ischemia (Smith et al., 1984), and glutamate excitotoxicity from NMDA (Vornov et al., 1991). The gene discussed is MAP3K12; the disease is Alzheimer disease.