Additionally, these tumors may harbor activating mutations in the JAK/STAT and NF-κB signaling pathways, including the inactivation of IκBα (NFKBIA) [7], a characteristic typically linked to activated B-cell (ABC) type diffuse large B-cell lymphoma (DLBCL), particularly in Epstein-Barr virus (EBV) positive cases [32]. This evidence concerns the gene NFKB1 and diffuse large B-cell lymphoma.