EZB subtype was primarily confined to GCB-DLBCL NOS (16%) and specific germinal center-derived DLBCL subtypes, such as T-cell Histiocyte-Rich B-cell Lymphoma and DLBCL/High-Grade B-cell Lymphoma with MYC and BCL2 dual hits. This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.