We showed that genetic ablation of PIK3CA in KPC (KrasG12D;Trp53R172H;Pdx1-Cre) pancreatic tumor cells led to T-cell recognition and complete elimination by the host immune system in a syngeneic orthotopic implantation mouse model (Sivaram et al., 2019). This evidence concerns the gene PDX1 and pancreatic neoplasm.