GJA1 and cancer: Moreover, it has been demonstrated that a decrease in Cx43 expression results in a reduced chemotherapeutic drug diffusion between cells and a decreased cytotoxicity, while Cx43 overexpression increases the sensitivity of cancer cells to several chemotherapeutic drugs, such as Doxorubicin, 5‐FU, and Oxaliplatin in different type of cancers [14, 15, 16], thus reducing resistance to drug treatments [17, 18].