As we have shown earlier, Alport nephropathy in 6-week-old Col4a3−/− mice is evident by considerable glomerulosclerosis, tubular atrophy, kidney injury, and αSMA+/Sirius Red+ interstitial fibrosis.25 Thus, we initiated treatments at a clinically relevant stage of CKD. The gene discussed is ACTA1; the disease is glomerulosclerosis.