To determine if these monocytes are involved in infection-induced osteoclastogenesis within the synovium, we conducted flow cytometric analyses, focusing on the expression levels of RANK, c-Fms (also known as colony-stimulating factor 1 receptor, CSF1R), and CCR2 in monocyte subgroups on day 3 after infection. The gene discussed is TNFRSF11A; the disease is infection.