However, elevated CA‐125 levels can also be present in benign conditions such as endometriosis, fibroids, pelvic inflammatory disease, pregnancy, as well as non‐gynecological conditions like peritonitis, pleurisy, pericarditis, or non‐gynecological malignancies from the digestive system or breast, particularly in the presence of intraperitoneal metastasis, which may restrict the test's diagnostic utility [110]. This evidence concerns the gene MUC16 and pericarditis.