INS and Hyperinsulinemia: In addition to lowering hyperinsulinemia, exenatide treatment was found to be superior to metformin in enhancing insulin sensitivity (HOMA-IR, FGP, oral glucose tolerance test (OGTT) 2 h glucose, OGTT 2 h insulin) in some studies (65, 66, 67), while others reported no significant distinctions between the two treatments (68).