GLP1R and obesity due to melanocortin 4 receptor deficiency: The decrease in obesity-related features through GLP-1 treatment was linked to positive effects on fasting glucose, insulin sensitivity (homeostatic model assessment for insulin resistance – HOMA-IR), metabolic syndrome and hormonal markers (testosterone, androstenedione and SHBG), but some studies were unable to demonstrate clinical endocrine benefits (menstrual frequency) (54, 56, 57).