We have reported that the survival of MDS cases with one TP53mut VAF < 50% with CK was comparable to those with 17p13.1 deletion on karyotype (10.4 vs. 11.0 months; p = 0.39) but was significantly poorer than those cases with monoallelic TP53mut without 17p loss or CK (10.4 vs. 33.4 months; p < 0.0001), indicating that for MDS cases with single TP53mut VAF < 50%, the presence of CK can be considered a practical surrogate for biallelic TP53 inactivation. Here, TP53 is linked to myelodysplastic syndrome.