NR4A1 and cancer: As indicated in the Introduction,diseases associated with exposures to high levels of PFAS have alinkage to NR4A1 and these adverse responses are ameliorated aftertreatment with an NR4A1 ligand such as celastrol, cytosporone B andrelated compounds, and CDIMs.38−46 For example, CDIM ligands act as inverse receptor agonists thatinhibit NR4A1-dependent pro-endometriotic and pro-carcinogenic responses,42,43 whereas higher PFAS levels in humans are associated with increasedendometriosis68,69 and cancer,9−23 respectively.