FOXO1 and cancer: DIM-3,5-Cl2 acts as an inverse NR4A1 agonist in cancer cells, and inRh30 cells, induction of proliferation by PFOS is inhibited by DIM-3,5-Cl2 (Figure 6C).Moreover, DIM-3,5-Cl2 also inhibits PFOS-induced NR4A1-regulatedPAX3-FOXO1 (FOXO1) and G9a gene products in Rh30 cells (Figure 6D).