LEP and obesity due to melanocortin 4 receptor deficiency: This phenomena could be explained by i) increased adiposity in the male SstKO-MSD offspring as leptin secretion is in proportion to the degree of obesity (Chessler et al. 1998) and ii) decreased insulin sensitivity in the male SstKO-MSD offspring as plasma leptin levels are often inversely correlated with insulin sensitivity (Echwald et al. 1999, Hung et al. 2006, Dagogo-Jack 2024).