GCG and Glucose intolerance: Therefore, glucose intolerance observed in male SstKO mice was likely caused by an increased fat deposit and a possible impaired hormone network due to the absence of somatostatin, which negatively regulates multiple hormone secretions, including insulin, glucagon, Glp1 and Pyy, and GH (Vu et al. 2001, Molitch 2011, Adriaenssens et al. 2015, Sekiya et al. 2020).