OGG1 and obesity due to melanocortin 4 receptor deficiency: For example, one study using a genetically obese mouse model (Ay/a) demonstrated that transgenic dams carrying and transmitting the human 8-oxoguanine DNA glycosylase gene (OGG1) protected transgenic offspring against diet-induced obesity through increased mitochondrial contents in adipocytes that balanced energy metabolism (Burchat et al. 2021).