To investigate the influence of maternal Sst deficiency on an offspring’s risk of developing obesity, insulin resistance and type 2 diabetes in their adult life, we randomized both male and female SstKO-MSD offspring born to the Sst-homozygous mothers and SstKO and WT offspring born to the Sst-heterozygous mothers on a regular chow diet (CD) or a HFD with 45% kcal from fat (HFD) for 15 weeks from weaning. This evidence concerns the gene SST and Insulin resistance.