Interestingly, some specific genes such as SPON2, a gene associated with enterocytes and CRC progression [45], PAX6, encoding a TF associated with enteroendocrine differentiation [46], and the goblet cell‐associated gene KRT7, which has been linked to metastasis [47], were specifically upregulated in basal medium with TGF‐β1 (Fig. S3.1, Table S2). This evidence concerns the gene PAX6 and colorectal carcinoma.