Interestingly, the CellChat analysis revealed that, compared to other pathways, such as CD46>>JAG1 and GZMA>>PARD3, the interaction of TGFβ>>TGFBR between Tregs and epithelial cells (particularly in cluster Epi_10_CYSTM1) was activated in ADC but not in SCC (Figure 7F and G). The gene discussed is TGFB1; the disease is AIDS dementia complex.