The 2020 American College of Rheumatology Guidelines for the Management of Reproductive Health in Rheumatic and Musculoskeletal Diseases recommend 4 mg/day oral dexamethasone for pregnant women positive for anti-SSA/Ro and/or anti-SSB/La antibodies, with UCG suggesting CHB presence in the foetus [89]. The gene discussed is TRIM21; the disease is musculoskeletal system disorder.