In contrast to the sustained glutamate metabolism, oxidative GABA metabolism was severely reduced in the 5xFAD mouse (Andersen, Christensen, et al. 2021) and in iPSC‐derived astrocytes of Alzheimer's disease patients (Salcedo et al. 2021), aligning well with lower activity of GABA‐T in brain samples of Alzheimer's disease (Sherif et al. 1992). The gene discussed is ABAT; the disease is early-onset autosomal dominant Alzheimer disease.