MUC16 and ovarian benign neoplasm: However, it is neither specific nor sensitive enough for accurate diagnosis as indicated by the National Comprehensive Cancer Network (http://www.nccn.org) because serum CA125 levels are influenced by a multitude of common conditions such as endometriosis, uterine fibroids, pelvic inflammatory disease, and benign ovarian tumor (Ghose et al. 2024).