Previously, we have published and demonstrated the specific roles of the ACE2 rs2074192, IFNAR2 rs2236757, OAS1 rs10774671, CD40 rs4813003, and CASP3 rs113420705 genes in predicting severe COVID-19 and multisystem inflammatory syndrome (MIS-C) in children (2). The gene discussed is CD40; the disease is COVID-19.