Our research indicated that certain polymorphisms in the genes ACE2 rs2074192, IFNAR2 rs2236757, OAS1 rs10774671, OAS3 rs10735079, CD40 rs4813003, FCGR2A rs1801274 and CASP3 rs113420705 could predict cytokine responses in pediatric COVID-19 patients. The gene discussed is CD40; the disease is COVID-19.