Xianlian Jiedu Decoction (XLJDD) treatment was effective in reducing the level of inflammatory response in a mouse model of colorectal cancer, the ability to reduce serum levels of inflammatory cytokines, and the ability to reduce levels of β-conjugated proteins, COX-2 and inducible nitric oxide synthase (iNOS) protein expression in colorectal tissue. Here, NOS2 is linked to colorectal cancer.