(ACE), which effectively delayed tumor progression in CT26 colon cancer-bearing mice, increased levels of SCFAs such as the gut microbial metabolites propionic acid and butyric acid in colon cancer cells and mediated the gut-derived stromal cell-derived factor-1 (SDF-1)/C-X-C chemokine receptor type 4 (CXCR 4) signaling pathway to inhibit tumor growth and metastasis (201). Here, CXCR4 is linked to malignant colon neoplasm.