Differential analysis between TCGA-LAML and GTEX-normal samples revealed that, in AML samples, the expression of CREB5, CSF3R, FPR1, CXCR2, KCNJ15, LILRB2, ITGAM, ITGB2, MAPK1, MAPK3, RIPK3 and SELPL was significantly downregulated compared with that in normal samples (Figure 2E). The gene discussed is CREB5; the disease is acute myeloid leukemia.