IL10 and Autoimmunity: Since expression of Il10 specifically occurs at both the Foxp3– and Foxp3+ TR1 cell stages, and IL-10 is necessary for therapeutic activity in all the animal models of autoimmunity tested to date, including EAE (7, 10), we studied the pharmacodynamic and therapeutic effects of pMOG38-49/I-Ab-NP therapy in pMOG35-55-immunized B6.Foxp3-Cre.