NLRP3 and early-onset autosomal dominant Alzheimer disease: Moreover, the expression of 84 inflammasome pathway-related genes was detected in LPS and Aβ42 stimulated monocytes of individuals diagnosed with severe AD, moderate Alzheimer’s disease (MILD), or mild cognitive impairment (MCI), and in age- and sex-matched healthy controls (HC), in which NLRP3 was significantly increased with the degree of AD (29).