To further investigate the changes of these members in AD, we then performed qPCR assay to test the expression levels of CIITA, NOD1, NLRP3, NLRC5, NLRP10, and NLRP12 in the hippocampus tissue in 6-month aged 5XFAD mouse model (Figure 3A). The gene discussed is NLRP12; the disease is Alzheimer disease.