As the results, we found that the NLRA subfamily member CIITA, the NLRC subfamily member NOD1 and NLRC5, and the NLRP subfamily member NLRP1, NLRP3, NLRP7, NLRP10, NLRP12, and NLRP13 levels significantly increased in hippocampus tissue samples of AD patients, as compared to their levels in the healthy controls (Figures 1A–C), suggesting these members might involve in the neuroinflammation and in the development of AD. Here, NLRC5 is linked to Alzheimer disease.