Furthermore, Chen Y. H. et al. (2023) discovered that the combination of AA and Lut resulted in a substantial upregulation of cleaved-PARP-1, Bax and cleaved Caspase-3, while concurrently downregulating the expression of Bcl-2 in cervical cancer CaSki and HeLa cells, thereby inducing caspase-mediated intrinsic apoptosis, Moreover, combination treatment with Lut and AsA more significantly decreased the PI3K(p110α), p-AKT, p-p70S6K, p-p38 and p-JNK1/2 expressions, and more synergistically increased the p-ERK1/2 expression level in both CaSki and HeLa Cells. The gene discussed is MAPK8; the disease is cervical carcinoma.