TGFB1 and neoplasm: In conclusion, AA effectively inhibited the migration and invasion of tumor cells, mainly by inhibiting Wnt/β-catenin, TGF-β, PI3K/AKT, VEGF/VEGFR2, p38MAPK and other signaling pathways, upregulating p53 and downregulating the expression of proteins such as FAK, Hsp90, LYVE-1, and VEGF-C(Its specific mechanism of suppressing metastasis and invasion is shown in Figure 3).