HMOX1 and asthma: Wang et al. (Wang S. B. et al., 2019) found that in a mouse model of ovalbumin (OVA)-induced asthma, Tan IIA may inhibit the increase of inflammatory cells in the blood by suppressing Th2 cytokine activity in lung tissue and inhibiting nuclear factor-κB (NF-κB) activation, while increasing heme oxygenase-1 (HO-1) activity.