Tai et al. (Tai et al., 2021) found that Tan IIA combined with cyclosporine A (CsA) improves mitochondrial function by up-regulating PI3K, p-Akt, p-Bad, and Bcl-2 expression, down-regulating Bax, Cyt-c, caspase-3, and PARP expression, and activating the PI3K/Akt/Bad signaling pathway in an ALI model induced by renal ischemia-reperfusion injury (IRI) in obese rats. The gene discussed is AKT1; the disease is acute respiratory distress syndrome.