Tan IIA also decreases the expression of prostaglandin endoperoxidase 2 (Ptgs2) and malondialdehyde (MDA), inhibits apoptosis and ferroptosis, reduces the expression of TNF-α, IL-6, and IL-1β, increases IL-10 expression, decreases the W/D ratio and MPO content, and increases SOD content, thereby alleviating I/R-induced acute lung injury. The gene discussed is MPO; the disease is injury.