Liu et al. (Liu et al., 2022) found that Tan IIA inhibits the ROCK2/NF-κB axis by suppressing ROCK2 expression in septic rats induced by cecal ligation and puncture (CLP) and lipopolysaccharide-treated RLE-6TN cells, down-regulating the expression of Bax and cleaved caspase-3 protein, and decreasing IL-1β, TNF-α, and IL-6 levels, thus alleviating lung tissue and cell injury and exerting anti-ALI/ARDS effects. The gene discussed is CASP3; the disease is acute respiratory distress syndrome.