Regarding trauma-induced ALI/ARDS, Liu et al. (Liu et al., 2020) reported that Tan IIA reverses the low expression of B-cell lymphoma 2 (Bcl2) and the high expression of Bax and caspase-3 after lung impact injury by down-regulating phosphorylated phosphatidylinositol-3-kinase (p-PI3K) and phosphorylated protein kinase B (p-Akt), up-regulating Forkhead transcription factor phosphorylation (p-FoxO1), and regulating the PI3K/Akt/FoxO1 signaling pathway in a shockwave-induced acute lung injury mouse model. Here, AKT1 is linked to acute lung injury.