NFKB1 and edema: Quan et al. (Quan et al., 2019) reported that Tan IIA upregulates the level of silent information regulator (Sirt1), decreases NF-kB p65 activity, and regulates the Sirt1/NF-kB signaling pathway, thereby down-regulating TNF-α, IL-1β, and IL-6 levels, reducing MPO activity, decreasing the W/D ratio of lung tissue, and improving the damaged alveolar structure and exudative pulmonary edema in lipopolysaccharide-induced mouse lung tissue.