In GC, TET promotes autophagy and cell apoptosis of HGC-27 cells by inhibiting activation of the PI3K/AKT signaling pathway and upregulating expression of autophagy-related markers (Beclin-1, LC3-II, and p62) as well as cleavage of apoptosis-related markers (caspase-3,caspase-9,and PARP) (Bai et al., 2018). This evidence concerns the gene SQSTM1 and gastric cancer.