Rottlerin, a natural polyphenol extracted from Mallotus philippinensis, has been shown by Song et al. to induce autophagy in a dose-dependent manner through the inhibition of mTOR and S-phase kinase-associated protein 2 expression, thereby mediating apoptosis in SGC-7901 and MGC-803 GC cell lines. The gene discussed is MTOR; the disease is gastric cancer.