BCL2 and gastric cancer: Interestingly, Xu et al. found that by altering the alkyl chain of Jaspine B to obtain its derivative C-2 and treating three different GC cells, the levels of pro-apoptotic proteins Bax and Cleaved-caspase9 were upregulated while the levels of anti-apoptotic proteins Bcl-2 and Bcl-xL were downregulated, inducing apoptosis in GC cells and exerting anti-proliferative activity.