Autophagy partially or completely regulates its own induction of cellular apoptosis through subfamilies JNK, p38, and ERK within the MAPK pathway, suggesting a collaborative relationship between autophagy and apoptosis in antitumor mechanism of Akebia saponin PA primarily associated with inducing autophagic cell death in GC cells (Xu et al., 2013). The gene discussed is MAPK1; the disease is gastric cancer.