In addition to inhibiting MAPK pathway and P13K/AKT/mTOR pathway to suppress GC cell proliferation, induce autophagy and apoptosis, BBR also inhibits AMPK pathway and NF-κB signaling pathway to reduce H. pylori-induced gastric mucosal inflammation, delaying or even reversing “inflammation-cancer” transformation. This evidence concerns the gene AKT1 and cancer.