Quercetin can activate BNIP3/BNIP3L, dissociate the interaction between Beclin-1 and Bcl-2/Bcl-xL, promote the inhibitory effect of HIF-1α on mTOR complex, mediate AKT and mTOR dephosphorylation, ultimately inducing autophagy in GC cells. The gene discussed is BECN1; the disease is gastric cancer.