ATG5 and neoplasm: It was found that autophagy occupies an important position in the anti-tumor activity of DIM, but the mechanism is not to induce autophagy activation, but to reverse the inhibitory effect of ATG5 by reducing the expression of miR-30e in BGC-823 cells, and to inhibit the proliferation of tumor cells by interfering with autophagosome degradation, indicating that DIM responds to the autophagic death of cancer cells by its cytotoxic effect (Ye et al., 2016).