As one of the most disrupted pathways in cancer, various activating mutations in oncogenes as well as inactivation of tumor suppressor genes can trigger abnormal activation of the PI3K/AKT/mTOR signaling pathway, which in turn regulates autophagy to participate in the malignant biological behaviors and prognosis of many types of tumors (Polivka and Janku, 2014). The gene discussed is PIK3CA; the disease is cancer.