Overexpression of AAMDC negatively affects GC cell proliferation inhibition and cell apoptosis, but Solanine can activate autophagy (promote LC3 conversion) and induce cell apoptosis by modulating AAMDC-related pathways in both GC mouse models and cellular models to prevent GC occurrence and inhibit tumor progression, thus confirming the potential of Solanine as a natural autophagy inhibitor for treating GC (Tang et al., 2023). The gene discussed is MAP1LC3A; the disease is gastric cancer.