HIF1A and gastric cancer: Jin et al. demonstrated that Apigenin (APG) inhibits HIF-1α and Ezh2 by suppressing mTOR signaling in GC and induces ER stress and autophagy-related cell death through the protein kinase RNA-like ER kinase-activating factor 4-C/EBP homologous protein (PERK-ATF4-CHOP) pathway in GC cells (Kim and Lee, 2021).