Cynaroside (Cy) has a wide range of pharmacological effects such as hepatoprotective, anti-diabetic, anti-inflammatory, and anti-cancer, and Ji et al. proposed that the MET/AKT/mTOR axis may be one of the important targets for Cy to regulate various biological processes such as GC cell proliferation, apoptosis, autophagy, and invasion to exert anti-cancer properties (Ji et al., 2021). This evidence concerns the gene AKT1 and cancer.