PIK3CA and neoplasm: Jaridon 6, a novel diterpenoid compound extracted from Rabdosia rubescens, possesses advantages in treating drug-resistant GC as it inhibits the PI3K/AKT pathway to suppress SIRT1 enzyme activity and induce compensatory autophagic cell death in resistant tumor cells as compensation for resistance to apoptosis of tumor cells (Fu L. et al., 2021).