GPX4 and gastric cancer: Moreover, recent studies have confirmed that targeting inactive PI3K/AKT/mTOR pathways with CUR can induce autophagy-mediated ferroptosis, characterizing by increased levels of Fe2+, MDA, lipid ROS as well as acyl-CoA synthetase long-chain family member 4 (ACSL4), a key biological marker for ferroptosis induction; meanwhile suppressing GSH expression levels along with SLC7A11 and GPX4 in GC cells, ultimately leading to suppression of GC cell growth (Zheng X. et al., 2024).