Saikosaponin D (SSD), an active monomer derived from traditional plant Bupleurum chinense DC., not only synergistically promotes GC cells apoptosis with DDP but also induces autophagic cell death by regulating LC3-B and p62 expression through inhibition of I kappa B kinase (IKK) β/NF-κB pathway. This evidence concerns the gene SQSTM1 and gastric cancer.