Raha et al. attributed the inhibitory effect of Nar on tumor growth to its ability to activate ERK1/2,JNK,and p38 MAPK members within the MAPK family which then suppresses the PI3K/AKT/mTOR cascade reaction resulting in autophagy-related growth inhibition specifically targeting GC cells (Raha et al., 2015). The gene discussed is PIK3CA; the disease is neoplasm.