Beyond CF, as a key regulator of intestinal fluid homeostasis, CFTR, is also implicated in other intestinal disorders including secretory diarrhea, chronic constipation and colorectal cancer (CRC) (Thiagarajah et al., 2015; Chang et al., 2023; Spelier et al., 2024; Shi et al., 2021). Here, CFTR is linked to Chronic constipation.