VEGFA and diabetes mellitus: ACNO possesses several advantages for wound healing, including inhibiting the growth of bacteria on the wound surface, alleviating inflammatory response in the wounds, upregulating the expression of CD34, endothelial NO synthase (eNOS), inducible NO synthase (iNOS), and vascular endothelial growth factor (VEGF), as well as promoting wound healing in diabetes by regulating the Wnt/β-catenin signaling pathway.