Santana et al. (2019) showed sakuranetin inhibited of MAPK and STAT3-SOCS3 to attenuate chronic allergic airway inflammation in mice. Weixiong Chen et al. showed She-Chuang-Si-Wu-Tang alleviates inflammation and itching symptoms in a psoriasis mouse model by regulating the Th17/IL-17 axis via the STAT3/MAPK pathways (Chen et al., 2024). Here, SOCS3 is linked to psoriasis.