Beyond the Hippo pathway, the prostaglandin E (PGE) (2) signaling pathway enhances YAP1 expression and activity, upregulating cyclocyception 2 and prostaglandin E receptor 4 (EP4), stimulating colon cancer cell proliferation and colon tissue regeneration in colitis mice [443]. Here, YAP1 is linked to malignant colon neoplasm.