YAP curtails myocardial ischemia/reperfusion injury‐induced ferroptosis by enhancing the transcription of neural precursor cell expressed developmentally downregulated 4‐2, which leads to the subsequent ubiquitination and degradation of Acyl coenzyme A (Acyl‐CoA) synthetase long‐chain family member 4 (ACSL4) [153] (Figure 2). This evidence concerns the gene YAP1 and myocardial ischemia.