Increased YAP levels play a role in CRSwNP epithelial barrier damage via the transforming growth factor‐β1 (TGF‐β1) signaling pathway, leading to the downregulation of TGF‐β1, zonula occludens‐1, and E‐cadherin protein levels [43]. This evidence concerns the gene TGFB1 and chronic rhinosinusitis with nasal polyps.