Ang362, as the transcriptional host, upregulates the expression of miR‐221 and miR‐222, activates the downstream NF‐κB signaling pathway, promotes the proliferation and migration of HPASMCs, inhibits their apoptosis, and triggers an inflammatory reaction, thereby promoting the occurrence and development of PAH [302]. The gene discussed is NFKB1; the disease is pulmonary arterial hypertension.