Mechanistically, lnc‐536 functions as a decoy for the RNA‐binding protein RBM25 (RNA binding motif protein 25), sequestering splicing factor proline‐and glutamine‐rich and leading to reduced HOXB13 expression, which contributes to smooth muscle hyperplasia in PAH [332]. The gene discussed is HOXB13; the disease is pulmonary arterial hypertension.