Knocking down E‐cadherin in CRC cells partially reversed the ability of F. nucleatum to induce phosphorylation of KLF4, without affecting the phosphorylation of the transcription factors C/EBPβ, Sp‐1 or c‐Jun, which are also known to turn on expression of integrin α5 [26, 27] (Figure 4B). This evidence concerns the gene SP1 and colorectal carcinoma.