SHPK and liver disorder: The top 10 interacting proteins were ACAT3, GSTM6, KYAT1, PTER, GCHFR, CSTB, SHPK, STAT3, NDUFA2, and PNPO, among which STAT3 plays a crucial role in the pathogenesis of liver diseases and is therefore identified as a prime target of carabrone [23].