In respiratory tract, CD8+TRM cells are strategically located in areas like the nasal epithelial tissue of the upper respiratory tract and the pulmonary interstitium of the lower respiratory tract, where they can rapidly respond to infections by respiratory viruses, including IAV, respiratory syncytial virus (RSV), and severe acute respiratory syndrome coronavirus (SARS‐CoV) [5, 80, 147–152]. This evidence concerns the gene CD8A and infection.