CD8A and neoplasm: While prior studies have established Tpex cells as primary responders to ICB [32, 33, 34], demonstrating their role in proliferative expansion and differentiation into more effector‐like exhausted CD8+T (Tex) cells [35], recent findings have highlighted the importance of tumor‐specific stem‐like memory CD8+T (Ttsm) cells in tumor‐draining lymph nodes (TdLNs) as also being bona fide responders to ICB [36].