CD8A and malaria: In another context, to generate robust liver CD8+TRM cell responses against malaria, naïve CD8+T cells are firstly activated by intramuscular immunization using recombinant viral vectors or DNA expressing malaria protective epitopes, then primed CD8+T cells are recruited to the liver through methods such as intravenous infection with a recombinant adeno‐associated virus vector (target) or by using attenuated sporozoites (trap) [191, 192].