SBF1 and microcephaly: Surprisingly, our brain-enriched transcriptomic analysis suggests that MTMR5 may regulate chromatin remodelling/organization pathway in the brain, mirroring our recent findings of epigenetic changes associated with knockout of another myotubularin family member (MTM1) in skeletal muscle.43 Future work is needed to unravel the role(s) of MTMR5 in neurons and brain development and establish why its loss causes microcephaly.