SBF1 and polyneuropathy: In addition, upon examining phenotypes in the peripheral nervous system (PNS), we observed disrupted axon patterning and dysmyelination in mtmr5-KO zebrafish, similar to the polyneuropathy reported in patients.25-27 Moreover, RNA sequencing using brain-enriched zebrafish cDNA identified changes in novel pathways (e.g. chromatin remodelling and synaptic biogenesis) that will guide future studies into the pathomechanisms underlying MTMR5-related brain abnormalities.