SQSTM1, or P62, is a multifunctional protein that plays a vital role in immunity and cellular autophagy.SQSTM1/P62 was initially identified as an autophagy junction consisting of the PB1/TRAF6 binding domain (TB)/LC3 interacting region (LIR)/ubiquitin-associated (UBA) structural domains, which are involved in autophagy and apoptosis in tumor cells (48). This evidence concerns the gene SQSTM1 and neoplasm.