The stimulation of 17β-estradiol (E2) enhances S-palmitoylation-dependent membrane localization of Estrogen Receptor beta (ERβ) and its interaction with Caveolin-1 and p38, ultimately promoting apoptosis in human colon adenocarcinoma DLD-1 cells via p38/MAPK pathway activation (76). This evidence concerns the gene ESR2 and colon adenocarcinoma.