Genomic testing through liquid biopsies plays a crucial role in detecting targetable lesions in solid tumors,43, 44, 45, 46 and this approach is equally relevant for IEM‐AML with the growing availability of targeted therapies, such as FLT3‐inhibitors, IDH1‐ and IDH2‐inhibitors, and Menin‐inhibitors.47 Here, FLT3 is linked to acute myeloid leukemia.