It did not include other existing risk factors of CVD/CAD-like dietary factors, occupational stress, smoking, physical activity, surrogate sensitive lipid markers of CAD like apolipoprotein B100/apolipoprotein A-I ratio, and other obesity-related inflammatory adipokines like serum leptin, resistin, TNF. This study included 400 participants in four phenotype groups of 100 each. This evidence concerns the gene RETN and obesity due to melanocortin 4 receptor deficiency.