Knockdown ofNCOA6 promotes the expression of acyl coenzyme a synthase long chain family member 4 (ACSL4) while inhibiting the expression of stearoyl coenzyme a desaturase 1 (SCD1), resulting in changes in lipid metabolism and sensitivity to RSL3-induced ferroptosis in pancreatic cancer cells. The gene discussed is ACSL4; the disease is familial pancreatic carcinoma.