Moreover, frequencies of Th2 cells, but not Tfh cells, in the draining mLNs of both UTXfl/fl and UTX-TCD mice were inversely correlated with peanut-induced anaphylaxis (i.e. drops in core body temperature of less than 2 °C) and peanut-specific IgE and IgG1 (Fig. 3). Here, IGHE is linked to anaphylaxis.