IGHE and anaphylaxis: Notably, the decline in peanut-specific IgE and blunting of peanut-induced anaphylaxis in the UTX-TCD mice compared to littermate controls also mirrored drops in peanut-specific IgE and reduced anaphylaxis severity previously reported by Xie et al. in mice lacking T-follicular regulatory (Tfr) cells that were sensitized to peanut with intragastric peanut + cholera toxin.13