Furthermore, it has been reported that mitochondria are fragmented in a DRP1-dependent manner for transportation and accumulation at the leading edge of invasive breast cancer cells, where they promote the production of local ATP essential for the formation of lamellipodia and for cell metastasis.45 The same phenomenon was observed in lung cancer, epithelial cancer, and thyroid cancer.13,46,47 These findings provide a reference for further understanding of the mechanism through which DRP1-mediated mitochondrial fission promotes metastasis in HNSCC. This evidence concerns the gene DNM1L and breast carcinoma.