LIMS1 and head and neck squamous cell carcinoma: Yan et al. observed that the binding of Circ_0098823 to IGF2BP3 regulates the expression of DRP1, thereby promoting HCC metastasis through mitochondrial fission.44 Xie et al. demonstrated that STMP1 promotes tumor metastasis by enhancing DRP1-mediated mitochondrial fission.15 We similarly identified a pro-carcinogenic role of PINCH-1 in enhancing the migration and invasion of HNSCC by promoting DRP1-mediated mitochondrial fission.