A previous study revealed that PINCH-1 is overexpressed in laryngeal squamous cell carcinoma (LSCC), and that its expression level is correlated with lymph node metastasis and poor pathological differentiation.33 Our study further demonstrated that PINCH-1 is not only overexpressed in LSCC, but also in other HNSCC types, including hypopharyngeal and oropharyngeal squamous cell carcinomas. The gene discussed is LIMS1; the disease is laryngeal squamous cell carcinoma.