PINCH-1 is an adaptor protein that interacts with several binding partners, activating downstream signaling pathways crucial for cell proliferation, survival, and motility.25 Elevated expression of PINCH-1 has been reported in various cancer types, indicating its association with the promotion of tumorigenesis.27,29,30 However, the biological role of PINCH-1 in HNSCC is yet to be explored. Here, LIMS1 is linked to head and neck squamous cell carcinoma.