PAK1 and cardiovascular disorder: This review indicating that inhibition of Pak1 may be effective in cardiovascular disorders is also reflected in earlier reviews and provides an indication of the complexity of modulation of Pak1 and the need for further understanding of the complexity of its signaling pathways and the development of specific therapeutic modifications that are appropriate for the context of the disorders in the cardiovascular system (Amirthalingam et al. 2021; Kelly et al. 2013).