As a bigenic methylation marker, PAX1/NREP‐AS1 (cg16767801 + cg23642047) was able to detect CIN3 or invasive cervical cancer with a sensitivity of 83%, specificity of 87%, and an AUC of 0.92 in a validation set, with a good predictive performance for CIN3 in an independent replication set. Here, NREP is linked to cervical carcinoma.