The CRC-related genes retrieved from DEGs, WGCNA and open access databases were combined with CWQ targets, and the Venn diagram showed that there were 14 common genes, including XDH, CDC25B, MAOA, AKR1B10, HSD11B2, CES2, ADH1C, CFD, HPGD, FABP1, ANPEP, CA9, CDKN2A, NR3C2 (Fig. 4A). The gene discussed is AKR1B10; the disease is colorectal carcinoma.