The CRC-related genes retrieved from DEGs, WGCNA and open access databases were combined with CWQ targets, and the Venn diagram showed that there were 14 common genes, including XDH, CDC25B, MAOA, AKR1B10, HSD11B2, CES2, ADH1C, CFD, HPGD, FABP1, ANPEP, CA9, CDKN2A, NR3C2 (Fig. 4A). This evidence concerns the gene CDKN2A and colorectal carcinoma.