Specifically, 5 genes (APOB, INSR, PPARG, APOC3, PDE3B) have human therapeutic evidence, 8 genes cause monogenic diseases that present with MASLD and/or metabolic dysfunction, 15 had animal model evidence, and 21 genes were differentially expressed in MASLD compared to control hepatocytes (Additional file 1: Table S24). This evidence concerns the gene APOB and metabolic dysfunction-associated steatotic liver disease.