To facilitate interpretation, we henceforth refer to variants and genes positively associated with MASLD as “risk” and those negatively associated with MASLD as “protective.” From single variant testing, the risk variant 19:7,629,499:G:T (XAB2) was positively associated with waist circumference and negatively associated with sex hormone binding globulin (SHBG), with low SHBG being a marker of hepatic steatosis and metabolic syndrome [22]. This evidence concerns the gene SHBG and metabolic syndrome.