Then, multiple Cox regression was performed, adjusting for the most relevant confounders (sex, smoking, hypertension, age, BMI, HbA1c, statin therapy, presence of T2D complications, eGFR, total cholesterol, and hs-CRP), obtaining a combined model that confirms the association between the increase of TyG index with higher mortality risk (HR = 1.33 (95% CI = 1.02–1.72); Table 2). This evidence concerns the gene CRP and Hypertension.