Even the point mutations in genes encoding certain subunits, e.g., ATPase or BAF250 in humans, lead to the development of various syndromes such as Coffin–Siris syndrome, Nicolaides–Baraitser syndrome, or nonsyndromic intellectual disability [42], while the loss of heterozygosity of the SMARCB1 gene encoding the INI1 subunit leads to the development of malignant rhabdoid tumors in children [43]. The gene discussed is SMARCB1; the disease is rhabdoid tumor.