Since forced expression of FET oncogenes caused an increase of global H3K27 trimethylation levels and an alteration of gene expression patterns in human HT1080 sarcoma cells, a shift in the antagonistic balance between SWI/SNF and PRC2, known to influence H3K27 trimethylation [113], was also proposed as a carcinogenic mechanism. This evidence concerns the gene SMARCA1 and sarcoma.