For example, BD mouse models of mania (Ankyrin-G conditional knockout, Clock19 deficient mice) show reduced immobility during TST (Zhu et al, 2017) and the FST (Roybal et al, 2007), suggesting that the reduced behavioral despair in our model could reflect a function of miR-708-5p in manic-like behavior. The gene discussed is ANK3; the disease is Behcet disease.