PDCD1 and neoplasm: Last, to confirm a direct role of VLCFAs and cholesterol in the phenotype modulations occurring in Elovl1-deficient CD8+ T cells, we performed ACT of sgElovl1 OT-I T cells pretreated with lignoceric acid or lovastatin in KPC_OVA tumour-bearing mice and treated them with anti-PD-1.