Higher mitochondrial functionality was also validated in vivo in sgElovl1 OT-I T cells infiltrating KPC_OVA primary tumour of mice treated with anti-PD-1 via MitoTracker staining and at the RNA level via gene set enrichment analysis (GSEA) of oxidative phosphorylation (Fig. 7e,f). The gene discussed is PDCD1; the disease is neoplasm.